![]() Kasperlik-Zaluska AA, Migdalska B, Czarnocka B, Drac-Kaniewska J, Niegowska E, Czech W. ![]() Associated autoimmunity in Addison's disease. Quality of Evidence lowered due to the risk of bias. Evidence 1 Moderate Quality of Evidence (moderate confidence that we know true effects of the intervention). ![]() Causes (also Table 6.1-1):ġ) Autoimmune disorders (most common). Symptoms of Addison disease develop when ~90% of the adrenal cortex is destroyed (this is preceded by subclinical Addison disease). Primary adrenal insufficiency ( AI), also termed Addison disease, is a clinical syndrome caused by a long-term deficit of hormones of the adrenal cortex, primarily cortisol and often aldosterone, due to a direct injury to the adrenal gland. ![]() Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. PMID: 33484633.īornstein SR, Allolio B, Arlt W, et al. Husebye ES, Pearce SH, Krone NP, Kämpe O. ![]()
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